Three different pharmacological efficacy in a single molecule- phenyramidol

Purpose: Phenyramidol was first described pharmacologically in 1959 and is used the treatment of painful musculoskeletal diseases. In this review, a collective evaluation silico, vitro, vivo, clinical studies Phenyramidol, whose analgesic myorelaxant efficacy initially defined, performed. Our aim to elucidate effects, safety, tolerability profile Phenyramidol. Method: Literature retrieved by PubMed search, using different combinations pertinent keywords (e.g., phenyramidol, spasm, pain, disorders), without any limitations terms publication date language. Papers that assessed therapeutic phenyramidol were selected for inclusion according their relevance topic, as judged authors. Results: studies, it has been reported exhibits an effective safe analgesic, anti-inflammatory activity with equivalent potency Codeine Meperidine. It shown use oral or intramuscular option provides up 94% improvement disorders tolerable 96.8% patients. No addictive effects serious adverse on cardiovascular system have observed due oral, parenteral, concomitant parenteral does not cause toxicity, effect, significant side gastrointestinal even at daily dosages 3200 mg. mutagenic patients incidence be similar placebo. strong vivo addition having statistically higher than thiocolchicoside acetylsalicylic acid, Ibuprofen Dexamethasone through balanced cyclooxygenase enzyme inhibition. Conclusion: which contains three pharmacological efficacies are potent its can choice symptomatic